Juxtapid® may help lower your numbers

If your doctor diagnosed you with HoFH (homozygous familial hypercholesterolemia) and you have been struggling to lower cholesterol even while taking other cholesterol-lowering therapies, adding Juxtapid may help.

Juxtapid is a prescription medicine used along with a low-fat eating plan and other cholesterol-lowering therapies in adults with HoFH to lower bad (LDL) cholesterol.

In a study of 29 adults with HoFH who were already taking other medications to lower their cholesterol, adding Juxtapid significantly reduced bad (LDL) cholesterol and total cholesterol.

Juxtapid reduced
bad cholesterol
by an average of
at 6 months
Juxtapid reduced total cholesterol
by an average of
at 6 months
Study detail

Everyone in the study started on a low daily dose of 5 mg of Juxtapid. The dose was slowly increased over time, based on individual safety and side effects, up to a maximum dose of 60 mg. Six people stopped taking Juxtapid during the first 6 months of the study.

The results seen in the first 6 months of the study were also maintained over the next 12 months during the safety phase.

Juxtapid may cause serious side effects, including liver problems. For this reason, your doctor should do blood tests to check your liver before you start Juxtapid and while you are taking Juxtapid (especially if your dose is increased). If your tests show signs of liver problems, your doctor may lower your dose of Juxtapid or stop it altogether.


Track your cholesterol numbers and get the most out of your dose

Everyone responds to treatment differently—including those taking Juxtapid. When just starting Juxtapid, some people see results right away, others only see small reductions, some don't see any change, and others don't see changes until after their dose is increased. It is important to talk about your cholesterol numbers with your doctor. If your cholesterol numbers don't go down as low as you and your doctor had hoped, don't be discouraged. Talk to your doctor about the possibility of changing the strength of your dose.
Tracking cholesterol
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Record your current cholesterol levels and check back regularly to see your results over time. If you haven't gotten your cholesterol numbers recently, talk with your doctor about getting your cholesterol checked. Contact your insurance provider to confirm your individual coverage for lab tests.

Juxtapid works with other cholesterol-lowering treatments to help me get closer to my cholesterol goals.

Read Jason's story

Juxtapid is taken with other
cholesterol-lowering therapies




Other treatments, such as statins, may help lower your cholesterol to a certain degree.
Adding Juxtapid to your treatment plan may help further reduce your cholesterol numbers to get closer to the goal set with your doctor.
Juxtapid is not a statin
Since your liver's mechanism to remove cholesterol isn't working properly, Juxtapid works differently by reducing the amount of cholesterol your liver makes in the first place. This way, your body has less bad (LDL) cholesterol to remove from the bloodstream. Less bad (LDL) cholesterol in the bloodstream means your cholesterol numbers go down.

What is Juxtapid?

Juxtapid® (lomitapide) capsules is a prescription medicine used along with diet and other lipid-lowering treatments, including low-density lipoprotein (LDL) apheresis where available, in adults with homozygous familial hypercholesterolemia (HoFH) to reduce LDL (“bad”) cholesterol, total cholesterol, a protein that carries bad cholesterol in the blood (apolipoprotein B), and non-high-density lipoprotein cholesterol (non-HDL-C).

Studies have not been conducted to tell us whether Juxtapid can help prevent problems from high cholesterol, such as heart attack, stroke, death, or other health problems. Studies have also not been conducted to tell us whether Juxtapid is safe for use in people with high cholesterol who do not have HoFH, including those with heterozygous familial hypercholesterolemia (HeFH).


Juxtapid is available only through certified pharmacies that are enrolled in the Juxtapid REMS Program. Your doctor must be enrolled and certified in the program in order to prescribe Juxtapid.

Juxtapid may cause serious side effects including:

Liver problems

  • Juxtapid can cause liver problems such as increased liver enzymes or increased fat in the liver. For this reason, your doctor should do blood tests to check your liver before you start Juxtapid and while you are taking Juxtapid (especially if your dose is increased). 
  • You should tell your doctor if you have had liver problems in the past, including liver problems while taking other medicines.
  • Stomach problems can also be a symptom of liver problems. Tell your doctor right away if you have nausea; vomiting or stomach pain that gets worse, does not go away, or changes; fever; yellowing of your eyes or skin; feeling more tired than usual; or having flu-like symptoms while taking Juxtapid because these may be signs of liver problems.
  • Do not drink more than 1 alcoholic drink per day while taking Juxtapid.

Harm to your unborn baby

  • Do not take Juxtapid if you are pregnant, think you may be pregnant, or are planning to become pregnant.
  • You should have a negative pregnancy test result before you can start on Juxtapid. Use effective birth control while taking Juxtapid. If you become pregnant while taking Juxtapid, stop taking Juxtapid and call your doctor right away.

You should not take Juxtapid if you

  • Are taking medications known as moderate or strong CYP3A4 inhibitors (for example, certain medications used to treat bacterial, fungal, or viral infections, as well as certain medications used to treat depression, high blood pressure, or angina). These medications may affect how your body breaks down Juxtapid.
  • Have moderate to severe liver problems or active liver disease, including abnormal liver function tests.

Other possible side effects of Juxtapid:

  • The most common side effects of Juxtapid are stomach problems including diarrhea, nausea, vomiting, cramps/pain, indigestion, and/or gas. You may be able to reduce your chance of stomach problems by following an eating plan consisting of less than 20% of calories from fat.
  • Juxtapid makes it harder for some fat-soluble nutrients, such as vitamin E and fatty acids, to get into your body. Take supplements that contain fat-soluble vitamins each day while you take Juxtapid. Ask your doctor, nurse, or dietitian how to take them.

Tell your doctor if you have any side effect that bothers you or that does not go away. Stop taking Juxtapid and tell your doctor if you have severe diarrhea, especially if you also have lightheadedness, decreased urine output, or tiredness. These are not all the possible side effects of Juxtapid. For more information, speak with your doctor or pharmacist.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Juxtapid may affect the way other medicines work, and other medicines may affect how Juxtapid works.

You are encouraged to report negative side effects of prescription drugs to your doctor. You may also report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

This is the most important information about Juxtapid. For more detailed information, please see the Medication Guide and Prescribing Information.

All people featured on this site are real patients living with HoFH and were taking Juxtapid at the time of the photo shoot.


This information is intended for US healthcare providers

I am a US healthcare provider

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This information is intended for US healthcare providers

I am a US healthcare provider

Return to Juxtapid.com