Juxtapid® is a pill you take once a day

Juxtapid comes in different strengths to treat high cholesterol due to HoFH (homozygous familial hypercholesterolemia). Your doctor can customize your dose and change it at any time, as needed.

Your doctor will likely start you on a low dose of 5 mg per day. Depending on your cholesterol goals, your liver test results, and how well you tolerate Juxtapid, your doctor may increase or decrease your dose over time.

When just starting Juxtapid, some people see results right away, others only see small reductions, some don’t see any change, and others don’t see changes until after their dose is increased.

If your cholesterol doesn't go down as low as you and your doctor had hoped, don't be discouraged. Talk to your doctor about the possibility of changing the strength of your dose.

Juxtapid may cause harm to your unborn baby. If you are pregnant, think you may be pregnant, or are planning to become pregnant, do not take Juxtapid. You should have a negative pregnancy test before you start taking Juxtapid. Use effective birth control while taking Juxtapid. If you become pregnant while taking Juxtapid, stop taking Juxtapid and call your doctor right away. 

A photo of Amanda

When I didn’t see results right away, I talked to my doctor about increasing the strength of my dose.

Read Amanda's story

How to take Juxtapid


  • Do take by mouth, with a glass of water
  • Do take on an empty stomach (at least 2 hours after dinner or evening snack)
  • Do store Juxtapid at room temperature and keep in a tightly closed container
  • Do maintain a low-fat eating plan to help reduce stomach problems


  • Don’t take Juxtapid with food
  • Don’t drink more than 1 alcoholic drink per day
  • Don’t drink grapefruit juice or eat grapefruit
  • Why? Grapefruit juice and alcohol can alter the way the liver responds to some medications, including Juxtapid.

Nutritional supplements are an important part of your treatment plan. It is recommended that you take nutritional supplements to replace the essential fatty acids and vitamin E that are not absorbed by your body while taking Juxtapid. It is recommended to take these supplements in the morning with food. Do not take them at night with Juxtapid, as they do contain a small amount of fat.

Juxtapid and a low-fat eating plan go hand in hand

In addition to working in the liver, Juxtapid works in the small intestine and changes the way your body absorbs fat. As a result, fat from the foods you eat can't be absorbed as easily when you are taking Juxtapid. If you eat too much fat, you may experience stomach problems such as diarrhea and bloating.

Maintaining a low-fat eating plan is the best way to minimize this common side effect.

What can you do?

Set up a personalized eating plan with your dedicated Compass Registered Dietitian. A specially trained Compass Registered Dietitian will work with you at no cost to customize a low-fat eating plan that will fit into your individual tastes and lifestyle.

Follow the low-fat eating plan.
The low-fat eating plan will help minimize possible stomach problems associated with fat intake.

Talk to your doctor about your dose.
Your doctor can provide tips and suggestions on managing side effects, including stomach problems such as diarrhea and bloating.

Adding Juxtapid to your HoFH treatment plan means you will have access to a dedicated Compass support team

Your Compass team will help you start Juxtapid and will be there for you throughout your treatment. When you start Juxtapid, each member of the Compass team will reach out to you, answer any questions you may have, and help make starting Juxtapid as easy as possible.


What is Juxtapid?

Juxtapid® (lomitapide) capsules is a prescription medicine used along with diet and other lipid-lowering treatments, including low-density lipoprotein (LDL) apheresis where available, in adults with homozygous familial hypercholesterolemia (HoFH) to reduce LDL (“bad”) cholesterol, total cholesterol, a protein that carries bad cholesterol in the blood (apolipoprotein B), and non-high-density lipoprotein cholesterol (non-HDL-C).

Studies have not been conducted to tell us whether Juxtapid can help prevent problems from high cholesterol, such as heart attack, stroke, death, or other health problems. Studies have also not been conducted to tell us whether Juxtapid is safe for use in people with high cholesterol who do not have HoFH, including those with heterozygous familial hypercholesterolemia (HeFH).


Juxtapid is available only through certified pharmacies that are enrolled in the Juxtapid REMS Program. Your doctor must be enrolled and certified in the program in order to prescribe Juxtapid.

Juxtapid may cause serious side effects including:

Liver problems

  • Juxtapid can cause liver problems such as increased liver enzymes or increased fat in the liver. For this reason, your doctor should do blood tests to check your liver before you start Juxtapid and while you are taking Juxtapid (especially if your dose is increased). 
  • You should tell your doctor if you have had liver problems in the past, including liver problems while taking other medicines.
  • Stomach problems can also be a symptom of liver problems. Tell your doctor right away if you have nausea; vomiting or stomach pain that gets worse, does not go away, or changes; fever; yellowing of your eyes or skin; feeling more tired than usual; or having flu-like symptoms while taking Juxtapid because these may be signs of liver problems.
  • Do not drink more than 1 alcoholic drink per day while taking Juxtapid.

Harm to your unborn baby

  • Do not take Juxtapid if you are pregnant, think you may be pregnant, or are planning to become pregnant.
  • You should have a negative pregnancy test result before you can start on Juxtapid. Use effective birth control while taking Juxtapid. If you become pregnant while taking Juxtapid, stop taking Juxtapid and call your doctor right away.

You should not take Juxtapid if you

  • Are taking medications known as moderate or strong CYP3A4 inhibitors (for example, certain medications used to treat bacterial, fungal, or viral infections, as well as certain medications used to treat depression, high blood pressure, or angina). These medications may affect how your body breaks down Juxtapid.
  • Have moderate to severe liver problems or active liver disease, including abnormal liver function tests.

Other possible side effects of Juxtapid:

  • The most common side effects of Juxtapid are stomach problems including diarrhea, nausea, vomiting, cramps/pain, indigestion, and/or gas. You may be able to reduce your chance of stomach problems by following an eating plan consisting of less than 20% of calories from fat.
  • Juxtapid makes it harder for some fat-soluble nutrients, such as vitamin E and fatty acids, to get into your body. Take supplements that contain fat-soluble vitamins each day while you take Juxtapid. Ask your doctor, nurse, or dietitian how to take them.

Tell your doctor if you have any side effect that bothers you or that does not go away. Stop taking Juxtapid and tell your doctor if you have severe diarrhea, especially if you also have lightheadedness, decreased urine output, or tiredness. These are not all the possible side effects of Juxtapid. For more information, speak with your doctor or pharmacist.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Juxtapid may affect the way other medicines work, and other medicines may affect how Juxtapid works.

You are encouraged to report negative side effects of prescription drugs to your doctor. You may also report side effects to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

This is the most important information about Juxtapid. For more detailed information, please see the Medication Guide and Prescribing Information.

All people featured on this site are real patients living with HoFH and were taking Juxtapid at the time of the photo shoot.


This information is intended for US healthcare providers

I am a US healthcare provider

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This information is intended for US healthcare providers

I am a US healthcare provider

Return to Juxtapid.com