Q: Is Juxtapid (lomitapide) approved by the US Food and Drug Administration (FDA)?
A: Yes, the FDA approved Juxtapid in 2012 to be used along with other cholesterol-lowering therapies and a low-fat eating plan to treat HoFH (homozygous familial hypercholesterolemia).
Q: Can I get Juxtapid at my local pharmacy where I get all my other prescriptions?
A: Juxtapid is not available at local pharmacies. It is available only through certified pharmacies that are enrolled in the Juxtapid REMS Program. Juxtapid is delivered right to your door through our specialty pharmacy partners at Dohmen Life Science Services.
Q: Who will contact me before I start Juxtapid and why?
A: Compass consists of a team of educators with a background in nursing, registered dietitians, and customer care specialists. In the beginning, you’ll speak with each member of the team to make sure that your insurance and Juxtapid questions are answered, you’re on track with your eating plan, and your prescription is filled properly. From there, your support will be tailored to meet your specific needs.
Q: What are the supplements that come with Juxtapid and how do I take them?
A: Nutritional supplements are an important part of your treatment plan. It is recommended that you take nutritional supplements to replace the essential fatty acids and vitamin E that are not absorbed by your body while taking Juxtapid. Be sure to take one of each in the morning with food. Do not take them at night with Juxtapid as they do contain a small amount of fat.
Q: I already eat a healthy diet. Why do I need to speak with a dietitian?
A: The low-fat eating plan you need to follow while taking Juxtapid is different from traditional heart-healthy eating because all fats count. While taking Juxtapid, you should get less than 20% of your daily calories from fat. By doing this, you may be able to reduce the risk of experiencing stomach problems—the most common side effect of Juxtapid. Your Compass Registered Dietitian is specially trained to help you figure out the easiest way to personalize the low-fat eating plan so it works for you.
Q: Why do I need liver tests?
A: Because of the way Juxtapid works in the liver, it can cause liver problems such as increased liver enzymes or increased fat in the liver. Your doctor should perform blood tests to check your liver before you start Juxtapid, if your dose is increased, and while you take Juxtapid. This can help ensure that you aren’t showing elevated enzyme levels, which can be an early sign of liver problems. If you do show signs of liver problems, your doctor will either lower your dose or stop Juxtapid altogether.
Q: If I develop liver problems, will they go away after I stop taking Juxtapid?
A: In clinical studies, elevated liver enzymes went back down after patients either reduced the dose or stopped taking Juxtapid.