The narrowing and hardening of arteries, caused by high cholesterol in the blood, which limits the flow of blood to organs and other parts of the body.


A substance made mainly by the liver, but also found in some foods, that circulates in the blood. The body needs cholesterol to stay healthy, but too little of one type and too much of another can cause health problems. Also see LDL.

Compass Care Manager

Member of your dedicated Compass team who works to help make the insurance process easier for you, helps you understand the cost of your treatment, and can refer you to independent financial assistance programs.

Compass Clinical Patient Educator

Member of your dedicated Compass team who personally guides you through what you need to know about HoFH and cholesterol.  You’ll learn what you can do to help manage HoFH, how Juxtapid works, and steps to get started.


Relating to something you inherited from your parents. If a health problem is genetic, it means you inherited the problem genes from at least one of your parents.

HeFH (heterozygous familial hypercholesterolemia)

A serious inherited condition in which the problem genes are passed down from one side of the family and cause high cholesterol. Studies have not been conducted to tell us whether Juxtapid is safe for use in people with high cholesterol that do not have HoFH, including those with HeFH.

HoFH (homozygous familial hypercholesterolemia)

A serious inherited condition in which the problem genes are passed down from both sides of the family and cause high cholesterol. HoFH is the least common and most severe form of FH.


Something passed down through one or both of your parents’ genes. If a health problem is inherited, it means a problem gene caused it.

LDL (low-density lipoprotein) cholesterol

Also known as “bad” cholesterol. If LDL cholesterol is too high, it can build up in arteries, and may cause health problems.

Liver monitoring

When taking certain medications such as Juxtapid®, your doctor will perform blood tests to check if your liver is functioning normally, as well as look for signs of liver problems.

Low-fat eating plan

While many people with high cholesterol are encouraged to stick to a heart-healthy diet, the Juxtapid low-fat eating plan is somewhat different because it is intended to help people avoid common stomach problems such as diarrhea and nausea.

Other cholesterol lowering medications

Prescription medicines that are used to reduce the amount of bad (LDL) cholesterol in the blood in the general population.

Registered dietitian

An expert in proper nutrition and specialized diets (for example, a heart-healthy or gluten-free diet). Dietitians help people develop an eating plan based on their specific dietary needs and preferences.

Safety phase

A part of a study that is designed to monitor the safety and tolerability of a specific drug.