HoFH, or homozygous familial hypercholesterolemia, is a form of high cholesterol that is rare and inherited. It can be difficult to treat using only other methods of lowering cholesterol, including diet and other therapies.
Why? To better understand, it’s helpful to know a little about how the body makes cholesterol and why this process is different in people with HoFH.
While we get some cholesterol from the foods we eat, the liver is responsible for producing most of the cholesterol found in our body.
The liver is responsible for making cholesterol and releasing it into the bloodstream for the body to use, as well as bringing back unused bad cholesterol for breakdown.
But if you have HoFH, your liver is different.
For adults with HoFH, there are 2 important types of cholesterol to keep track of:
Consistently elevated cholesterol can build up in your arteries and can lead to atherosclerosis.
Your cholesterol goals may be different. If you do not have a goal, ask your doctor to set one with you.
We follow a low-fat eating plan as a family now. We have been avoiding oils and fats, and we don’t really miss them.”
Juxtapid® (lomitapide) capsules is a prescription medicine used along with diet and other lipid lowering treatments, including low-density lipoprotein (LDL) apheresis where available, in adults with homozygous familial hypercholesterolemia (HoFH) to reduce LDL (“bad”) cholesterol, total cholesterol, a protein that carries bad cholesterol in the blood (apolipoprotein B), and non-high-density lipoprotein cholesterol (non-HDL-C).
Studies have not been conducted to tell us whether Juxtapid can help prevent problems from high cholesterol, such as heart attack, stroke, death, or other health problems. Studies have also not been conducted to tell us whether Juxtapid is safe for use in people with high cholesterol but who do not have HoFH, including those with heterozygous familial hypercholesterolemia (HeFH).
Juxtapid is available only through certified pharmacies that are enrolled in the Juxtapid REMS Program. Your doctor must be enrolled and certified in the program in order to prescribe Juxtapid.
Tell your doctor if you have any side effect that bothers you or that does not go away. Stop taking Juxtapid and tell your doctor if you have severe diarrhea, especially if you also have lightheadedness, decreased urine output, or tiredness. These are not all the possible side effects of Juxtapid. For more information, speak with your doctor or pharmacist.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Juxtapid may affect the way other medicines work, and other medicines may affect how Juxtapid works.