Juxtapid® is made to lower cholesterol in adults with HoFH
People with HoFH (homozygous familial hypercholesterolemia) have trouble removing unused bad cholesterol from the bloodstream because the mechanism for removing bad cholesterol from the bloodstream does not work properly.
Medications such as statins rely on a well-functioning mechanism to remove cholesterol—which is why they may not be enough to help people with HoFH reach their target cholesterol level set with their doctor.
Since your liver’s mechanism to remove cholesterol isn’t working properly, Juxtapid limits the amount of bad cholesterol your liver makes in the first place. This way, your body has less bad cholesterol to remove from the bloodstream.
Juxtapid works in your liver
to limit the amount of cholesterol the liver makes
so there is less cholesterol in your bloodstream
Potential liver problems and why they can happen
Because of the way Juxtapid works in the liver, liver problems can happen in some people. Your doctor will monitor your liver through regular blood tests to make sure you aren't showing signs of liver problems.
What your doctor will do
Your doctor should perform blood tests to check your liver before you start Juxtapid, if your dose is increased, and while you are taking Juxtapid.
Blood test results will tell your doctor if certain liver enzyme levels are higher than usual. Higher enzyme levels can be an early sign of liver problems. If your tests show signs of liver problems, your doctor may reduce your dose or stop Juxtapid altogether. In Juxtapid studies, elevated liver enzyme levels went back down after either stopping or reducing the dose of Juxtapid.